2023-04-052023-04-0520197177518https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000300303&lng=en&nrm=iso&tlng=enhttp://146.190.124.33/handle/123456789/5636http://dx.doi.org/10.4067/S0717-75182019000300303The aim of the study was to determine the nephroprotective effect of camu camu extract on a gentamicin-induced nephrotoxicity model. The study design was experimental using 50 Sprague Dawley rats randomly allocated into 1 of 5 five groups: a control group that was administered a saline solution, a gentamicin group in which nephrotoxicity was induced and experimental groups 1, 2 and 3 that were provided different doses of Camu Camu alcoholic extract. Nephroprotective activity was evaluated via quantification of seric creatinine, histopathological analysis and weighing of the kidneys. Results showed a significant decrease in creatinine levels between the group administered camu camu alcoholic extract and the gentamicin group (p<0.05). Groups who received camu camu presented a gradual increase in kidneys weight which corresponded directly to the extract dose (p<0.05). The histopathological analysis showed epithelial loss, intense inflammatory infiltrate and vascular congestion in the gentamicin group, while the groups who received the extract had a lower level of damage. Camu Camu extract provided a significant nephroprotective activity on a gentamicin-induced nephrotoxicity model. © 2019, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved.spainfo:eu-repo/semantics/article