Roa, I.Cantín M., Muñoz M., Rosas C., Lemus D.6/22/20222022-06-226/22/20222022-06-222016https://doi.org/10.4067/S0717-95022016000100048Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable to other tumor lines, concluding that Celecoxib/poli(lactic-co-glycolic) acid is a potential candidate in antitumor therapy. © 2016, Universidad de la Frontera. All rights reserved.application/pdfenginfo:eu-repo/semantics/closedAccessMedicineinfo:eu-repo/semantics/article10.4067/S0717-95022016000100048http://purl.org/pe-repo/ocde/ford#2.00.00