Serum uric acid levels contribute to new renal damage in systemic lupus erythematosus patients

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dc.contributor.authorReátegui-Sokolova, C.es_ES
dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorGamboa-Cárdenas, R.V.es_ES
dc.contributor.authorZevallos, F.es_ES
dc.contributor.authorCucho-Venegas, J.M.es_ES
dc.contributor.authorAlfaro-Lozano, J.L.es_ES
dc.contributor.authorMedina, M.es_ES
dc.contributor.authorRodriguez-Bellido, Z.es_ES
dc.contributor.authorPastor-Asurza, C.A.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.contributor.authorPerich-Campos, R.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:49:29Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:49:29Z
dc.date.issued2017
dc.description.abstractThis study aims to determine whether uric acid levels contribute to new renal damage in systemic lupus erythematosus (SLE) patients. This prospective study was conducted in consecutive patients seen since 2012. Patients had a baseline visit and follow-up visits every 6 months. Patients with ≥2 visits were included; those with end-stage renal disease (regardless of dialysis or transplantation) were excluded. Renal damage was ascertained using the SLICC/ACR damage index (SDI). Univariable and multivariable Cox-regression models were performed to determine the risk of new renal damage. Uric acid was included as a continuous and dichotomous (per receiving operating characteristic curve) variable. Multivariable models were adjusted for age at diagnosis, disease duration, socioeconomic status, SLEDAI, SDI, serum creatinine, baseline use of prednisone, antimalarials, and immunosuppressive drugs. One hundred and eighty-six patients were evaluated; their mean (SD) age at diagnosis was 36.8 (13.7) years; nearly all patients were mestizo. Disease duration was 7.7 (6.8) years. Follow-up time was 2.3 (1.1) years. The SLEDAI was 5.2 (4.3) and the SDI 0.8 (1.1). Uric acid levels were 4.5 (1.3) mg/dl. During follow-up, 16 (8.6%) patients developed at least one new point in the renal domain of the SDI. In multivariable analyses, uric acid levels (continuous and dichotomous) at baseline predicted the development of new renal damage (HR 3.21 (1.39–7.42), p 0.006; HR 18.28 (2.80–119.48), p 0.002; respectively). Higher uric acid levels contribute to the development of new renal damage in SLE patients independent of other well-known risk factors for such occurrence. © 2017, International League of Associations for Rheumatology (ILAR).es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1007/s10067-017-3538-4es_ES
dc.identifier.urihttps://doi.org/10.1007/s10067-017-3538-4
dc.language.isoenges_ES
dc.publisherSpringer Londones_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceClinical Rheumatologyes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleSerum uric acid levels contribute to new renal damage in systemic lupus erythematosus patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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