Relevance of the carotid body chemoreflex in the progression of heart failure

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dc.contributor.authorAndrade, D.C.es_ES
dc.contributor.authorLucero, C.es_ES
dc.contributor.authorToledo, C.es_ES
dc.contributor.authorMadrid, C.es_ES
dc.contributor.authorMarcus, N.J.es_ES
dc.contributor.authorSchultz, H.D.es_ES
dc.contributor.authorDel Rio, R.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:09:26Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:09:26Z
dc.date.issued2015
dc.description.abstractChronic heart failure (CHF) is a global health problem affecting millions of people. Autonomic dysfunction and disordered breathing patterns are commonly observed in patients with CHF, and both are strongly related to poor prognosis and high mortality risk. Tonic activation of carotid body (CB) chemoreceptors contributes to sympathoexcitation and disordered breathing patterns in experimental models of CHF. Recent studies show that ablation of the CB chemoreceptors improves autonomic function and breathing control in CHF and improves survival. These exciting findings indicate that alterations in CB function are critical to the progression of CHF. Therefore, better understanding of the physiology of the CB chemoreflex in CHF could lead to improvements in current treatments and clinical management of patients with CHF characterized by high chemosensitivity. Accordingly, the main focus of this brief review is to summarize current knowledge of CB chemoreflex function in different experimental models of CHF and to comment on their potential translation to treatment of human CHF. © 2015 David C. Andrade et al.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1155/2015/467597es_ES
dc.identifier.urihttps://doi.org/10.1155/2015/467597
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceBioMed Research Internationales_ES
dc.subjectBiochemistry, Genetics and Molecular Biologyes_ES
dc.subjectImmunology and Microbiologyes_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#1.06.03es_ES
dc.titleRelevance of the carotid body chemoreflex in the progression of heart failurees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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