Case report: Mucosal leishmaniasis presenting with nasal septum perforation after almost thirty years

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dc.contributor.authorRojas-Jaimes, J.es_ES
dc.contributor.authorFrischtak, H.L.es_ES
dc.contributor.authorArenas, J.es_ES
dc.contributor.authorLescano, A.G.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T17:01:49Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T17:01:49Z
dc.date.issued2018
dc.description.abstractMucosal leishmaniasis (ML) is associated with progressive tissue destruction and granuloma formation, often after a considerable period of latency from an initial cutaneous infection. We report a case of recurrent epistaxis of 3 years duration and nasopharyngeal obstruction in a woman with treated cutaneous leishmaniasis nearly 30 years before and with no further exposure to Leishmania. Computed tomography revealed nasal septal perforation and histopathology demonstrated chronic inflammation. Microscopy was negative for amastigotes, but molecular testing of nasal mucosa biopsy detected Leishmania (Viannia) braziliensis. The patient underwent 28 days of treatment with IV sodium stibogluconate and her symptoms improved significantly. Sixteen months after treatment, she continues to have episodic epistaxis and detectable parasite load in her nasal lesion. Although ML is known to take years to decades to develop, there are few reported cases in the literature of such a long latency period. This report highlights the importance of considering ML in the differential diagnosis of chronic epistaxis in countries where leishmaniasis is endemic or in immigrants from these countries, even when presentation occurs decades after leaving an endemic region. Copyright © 2018 by The American Society of Tropical Medicine and Hygiene.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.4269/ajtmh.17-0831es_ES
dc.identifier.urihttps://doi.org/10.4269/ajtmh.17-0831
dc.language.isoenges_ES
dc.publisherAmerican Society of Tropical Medicine and Hygienees_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceAmerican Journal of Tropical Medicine and Hygienees_ES
dc.subjectImmunology and Microbiologyes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.02.14es_ES
dc.titleCase report: Mucosal leishmaniasis presenting with nasal septum perforation after almost thirty yearses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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