Efecto nefroprotector del Camu Camu (Myrciaria dubia) en un modelo de nefrotoxicidad inducida por gentamicina en ratas [Nephroprotective effect of Camu Camu (Myrciaria dubia) in a model of nephrotoxicity induced by gentamicin in rats]
| dc.date.accessioned | 2023-04-05T12:45:31Z | |
| dc.date.available | 2023-04-05T12:45:31Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The aim of the study was to determine the nephroprotective effect of camu camu extract on a gentamicin-induced nephrotoxicity model. The study design was experimental using 50 Sprague Dawley rats randomly allocated into 1 of 5 five groups: a control group that was administered a saline solution, a gentamicin group in which nephrotoxicity was induced and experimental groups 1, 2 and 3 that were provided different doses of Camu Camu alcoholic extract. Nephroprotective activity was evaluated via quantification of seric creatinine, histopathological analysis and weighing of the kidneys. Results showed a significant decrease in creatinine levels between the group administered camu camu alcoholic extract and the gentamicin group (p<0.05). Groups who received camu camu presented a gradual increase in kidneys weight which corresponded directly to the extract dose (p<0.05). The histopathological analysis showed epithelial loss, intense inflammatory infiltrate and vascular congestion in the gentamicin group, while the groups who received the extract had a lower level of damage. Camu Camu extract provided a significant nephroprotective activity on a gentamicin-induced nephrotoxicity model. © 2019, Sociedad Chilena de Nutricion Bromatologia y Toxilogica. All rights reserved. | |
| dc.identifier.issn | 7177518 | |
| dc.identifier.uri | https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182019000300303&lng=en&nrm=iso&tlng=en | es_PE |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/5636 | |
| dc.identifier.uri | http://dx.doi.org/10.4067/S0717-75182019000300303 | es_PE |
| dc.language.iso | spa | es_ES |
| dc.publisher | Sociedad Chilena de Nutricion Bromatologia y Toxilogica | es_ES |
| dc.source | New Microbes and New Infections; Vol. 49-50 | |
| dc.title | Efecto nefroprotector del Camu Camu (Myrciaria dubia) en un modelo de nefrotoxicidad inducida por gentamicina en ratas [Nephroprotective effect of Camu Camu (Myrciaria dubia) in a model of nephrotoxicity induced by gentamicin in rats] | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |