Efecto gastroprotector del extracto etanólico de Clinopodium bolivianum (Benth.) Kuntze "sayqa muña" sobre lesiones ulcerosas inducidas en ratones albinos Balb-C
Fecha
2014
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Editor
Universidad Nacional San Luis Gonzaga
Resumen
Clinopodium bolivianum, conocida como "sayqa muña", es utilizada en la medicina tradicional para tratar problemas digestivos. Este estudio determinó que el extracto etanólico de la planta contiene 92,12 mgEAG/g de polifenoles totales. La actividad antioxidante del extracto fue evaluada mediante el ensayo DPPH, mostrando una inhibición de radicales libres comparable a la vitamina C. El efecto gastroprotector se probó en diferentes dosis, siendo la dosis de 300 mg/kg la más efectiva, similar a 50 mg/kg de ranitidina. Los resultados sugieren que el extracto tiene una alta actividad gastroprotectora, probablemente debido a la presencia de flavonoides y otros metabolitos secundarios.
Abstract Clinopodium bolivianum, known as "sayqa muña", is used in traditional medicine for digestive treatments. This study determined that the ethanolic extract of the plant contains 92.12 mgEAG/g of total polyphenols. The antioxidant activity of the extract was evaluated using the DPPH assay, showing free radical inhibition comparable to vitamin C. The gastroprotective effect was tested at different doses, with 300 mg/kg being the most effective, similar to 50 mg/kg of ranitidine. The results suggest that the extract has high gastroprotective activity, likely due to the presence of flavonoids and other secondary metabolites.
Abstract Clinopodium bolivianum, known as "sayqa muña", is used in traditional medicine for digestive treatments. This study determined that the ethanolic extract of the plant contains 92.12 mgEAG/g of total polyphenols. The antioxidant activity of the extract was evaluated using the DPPH assay, showing free radical inhibition comparable to vitamin C. The gastroprotective effect was tested at different doses, with 300 mg/kg being the most effective, similar to 50 mg/kg of ranitidine. The results suggest that the extract has high gastroprotective activity, likely due to the presence of flavonoids and other secondary metabolites.
Descripción
Universidad Nacional San Luis Gonzaga de Ica, Facultad de Farmacia y Bioquímica. Tesis para optar el título profesional de Farmacia y Bioquímica.
Asesores Dra. Francisca Martha Garcia Wong Mg. Oscar Herrera Calderon
Asesores Dra. Francisca Martha Garcia Wong Mg. Oscar Herrera Calderon
Palabras clave
Planta Medicina, Clinopodium Bolivianum (Inca Muña), Gastroprotector, Lesiones gástricas, Indometacina, Etanol