Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease

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dc.contributor.authorIturriaga, R.es_ES
dc.contributor.authorDel Rio, R.es_ES
dc.contributor.authorIdiaquez, J.es_ES
dc.contributor.authorSomers, V.K.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:51Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:51Z
dc.date.issued2016
dc.description.abstractThe carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1186/s40659-016-0073-8es_ES
dc.identifier.urihttps://doi.org/10.1186/s40659-016-0073-8
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceBiological researches_ES
dc.subjectAgricultural and Biological Scienceses_ES
dc.subjectBiochemistry, Genetics and Molecular Biologyes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#4.01.00es_ES
dc.titleCarotid body chemoreceptors, sympathetic neural activation, and cardiometabolic diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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