Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of peruvian tuberculosis patients
| dc.date.accessioned | 2023-04-05T12:48:11Z | |
| dc.date.available | 2023-04-05T12:48:11Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Background: We determined the frequency of genetic polymorphisms in three anti-TB drug metabolic proteins previously reported: N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), and arylacetamide deacetylase (AADAC) within a Peruvian population in a cohort of TB patients. Methods: We genotyped SNPs rs1041983, rs1801280, rs1799929, rs1799930, rs1208, and rs1799931 for NAT2; rs3813867 and rs2031920 for CYP2E1; and rs1803155 for AADAC in 395 participants completed their antituberculosis treatment. Results: Seventy-four percent of the participants are carriers of slow metabolizer genotypes: NAT2*5, NAT2*6, and NAT2*7, which increase the sensitivity of INH at low doses and increase the risk of drug-induced liver injuries. Sixty-four percent are homozygous for the wild-type CYP2E1*1A allele, which could increase the risk of hepatotoxicity. However, 16% had a NAT2 fast metabolizer phenotype which could increase the risk of acquiring resistance to INH, thereby increasing the risk of multidrug-resistant (MDR) or treatment failure. The frequency of rs1803155 (AADAC*2 allele) was higher (99.9%) in Peruvians than in European American, African American, Japanese, and Korean populations. Conclusions: This high prevalence of slow metabolizers for isoniazid in the Peruvian population should be further studied and considered to help individualize drug regimens, especially in countries with a great genetic diversity like Peru. These data will help the Peruvian National Tuberculosis Control Program develop new strategies for therapies. © 2021 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC | |
| dc.identifier.issn | 23249269 | |
| dc.identifier.uri | https://doi.org/10.1002/mgg3.1764 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/6262 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | John Wiley and Sons Inc | es_ES |
| dc.source | Epidemiology and Health; Vol. 42 | |
| dc.title | Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of peruvian tuberculosis patients | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |