Association of -1082 interleukin-10 gene polymorphism in peruvian adults with chronic periodontitis

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dc.contributor.authorChambrone, L.es_ES
dc.contributor.authorAscarza, A.es_ES
dc.contributor.authorGuerrero, M.-E.es_ES
dc.contributor.authorPannuti, C.es_ES
dc.contributor.authorde la Rosa, M.es_ES
dc.contributor.authorSalinas-Prieto, E.es_ES
dc.contributor.authorMendoza, G.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:50Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:50Z
dc.date.issued2014
dc.description.abstractObjectives: The aim of this study was to assess association of the -1082 IL-10 gene polymorphism with chronic periodontitis CP in a Peruvian population.Study Design: Samples of venous blood and DNA were obtained from 106 Peruvian subjects: a) 53 periodontally healthy; and b) 53 with CP. The association of the -1082 IL-10 promoter sequences was assessed by Polymerase chain reaction-restriction fragment length polymorfism (PCR-RFLP). Student’s t test were used to assess the clinical parameters, as well as the χ2 test and the odds ratio (OR), with 95% confidence intervals (CI) used performed for estimates regarding genotype and allele frequencies.Results: There were statistically significant differences between groups regarding the mean bleeding on probing, mean attachment level and mean probing depth (p < 0.00001) indicating that the matching based on the evaluated groups was adequate. The χ2 test found a statistically significant imbalance of genotypes between groups (p = 0.0172). The prevalence of CP was significantly higher in subjects harboring at least one A allele at position -1082 (AA and GA genotypes) in comparison to patients with the GG genotype (OR = 2.96; CI: 0.52; 5.41; p = 0.0099). Equally, subjects with the AA genotype were significantly associated to a diagnosis of CP (OR = 2.71; CI: 0.38; 5.04; p = 0.0231). On the other hand, subjects presenting a healthy periodontal status presented at least one G allele in comparison with the AA genotype (OR = 0.37; CI: 0.05, 0.69; p = 0.0231). For subjects with the GG genotype, the same positive association was observed (OR = 0.34; CI: 0.06, 0.62; p = 0.0099). There were no significant differences between groups amongst subjects with the GA genotype (OR = 1.19; CI: 0.22, 2.16; p = 0.6774).Conclusions: Within the limits of this study, IL-10 gene polymorphism at position -1082 does not appear to be associated to CP. Conversely, subjects with AA genotype seem to be at an increased risk of developing CP. © Medicina Oral S. L.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.4317/medoral.19823es_ES
dc.identifier.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC4259372/es_PE
dc.identifier.urihttps://europepmc.org/article/PMC/4259372es_PE
dc.identifier.urihttps://dialnet.unirioja.es/servlet/articulo?codigo=4897994es_PE
dc.identifier.urihttps://siis.unmsm.edu.pe/en/publications/association-of-1082-interleukin-10-gene-polymorphism-in-peruvian--3/fingerprints/es_PE
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/25129246/es_PE
dc.language.isoenges_ES
dc.publisherMedicina Oral, Patologia Oral y Cirugia Bucales_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceMedicina Oral, Patología Oral y Cirugía Bucales_ES
dc.subjectDentistryes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.02.14es_ES
dc.titleAssociation of -1082 interleukin-10 gene polymorphism in peruvian adults with chronic periodontitises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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