Circulating CD4+CD28null and extra-thymic CD4+CD8+ double positive T cells are independently associated with disease damage in systemic lupus erythematosus patients

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dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorSánchez-Zúñiga, C.es_ES
dc.contributor.authorGamboa-Cárdenas, R.V.es_ES
dc.contributor.authorAliaga-Zamudio, M.es_ES
dc.contributor.authorZevallos, F.es_ES
dc.contributor.authorTineo-Pozo, G.es_ES
dc.contributor.authorCucho-Venegas, J.M.es_ES
dc.contributor.authorMosqueira-Riveros, A.es_ES
dc.contributor.authorMedina, M.es_ES
dc.contributor.authorPerich-Campos, R.A.es_ES
dc.contributor.authorAlfaro-Lozano, J.L.es_ES
dc.contributor.authorRodriguez-Bellido, Z.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.contributor.authorPastor-Asurza, C.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:34Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:34Z
dc.date.issued2016
dc.description.abstractObjective: To determine whether circulating CD4+CD28null and extra-thymic CD4+CD8+ double positive (DP) T cells are independently associated with damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This cross-sectional study was conducted between September 2013 and April 2014 in consecutive SLE patients from our Rheumatology Department. CD4+CD28null and CD4+CD8+ DP T-cell frequencies were analyzed by flow-cytometry. The association of damage (SLICC/ACR Damage Index, SDI) and CD4+CD28null and CD4+CD8+ DP T cells was examined by univariable and multivariable Poisson regression models, adjusting for possible confounders. All analyses were performed using SPSS 21.0. Results: Patients' (n = 133) mean (SD) age at diagnosis was 35.5 (16.8) years, 124 (93.2%) were female; all were mestizo (mixed Caucasian and Amerindian ancestry). Disease duration was 7.4 (6.8) years. The SLE Disease Activity Index was 5.5 (4.2), and the SDI 0.9 (1.2). The percentages of CD4+CD28null and CD4+CD8+ DP T cells were 17.1 (14.4) and 0.4 (1.4), respectively. The percentage of CD4+CD28null and CD4+CD8+ DP T cells were positively associated with a higher SDI in both univariable (rate ratio (RR) 1.02, 95% confidence interval (CI): 1.01-1.03 and 1.17, 95% CI: 1.07-1.27, respectively; p < 0.001 for both) and multivariable analyses RR 1.02, 95% CI: 1.01-1.03, p = 0.001 for CD4+CD28null T cells and 1.28, 95% CI: 1.13-1.44, p < 0.001 for CD4+CD8+ DP T cells). Only the renal domain remained associated with CD4+CD28null in multivariable analyses (RR 1.023 (1.002-1.045); p = 0.034). Conclusions: In SLE patients, CD4+CD28null and CD4+CD8+ DP T cells are independently associated with disease damage. Longitudinal studies are warranted to determine the predictive value of these associations. © The Author(s) 2015.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1177/0961203315604910es_ES
dc.identifier.urihttps://doi.org/10.1177/0961203315604910
dc.language.isoenges_ES
dc.publisherSAGE Publications Ltdes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceLupuses_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleCirculating CD4+CD28null and extra-thymic CD4+CD8+ double positive T cells are independently associated with disease damage in systemic lupus erythematosus patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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