Efecto protector y regenerativo del extracto puro de apio (Apium graveolens) en ratas (Rattus norvegicus) con daño hepático inducido por tetracloruro de carbono. Arequipa, 2014
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2015
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Universidad Nacional de San Agustín de Arequipa
Resumen
Se investigó el efecto protector y regenerativo del apio (Apium Graveolens) en ratas con daño hepático inducido por tetracloruro de carbono. Se utilizaron 42 ratas machos de tres meses, distribuidas en ocho grupos. Los grupos recibieron diferentes dosis de extracto de apio antes y después de inducir el daño hepático, además de grupos placebo y control. Se midieron las transaminasas TGO, TGP y GGT. El grupo preventivo que recibió 2.0 ml de extracto de apio mostró una reducción significativa en los niveles de GGT. Histológicamente, el apio administrado antes del daño redujo la necrosis celular de los hepatocitos y mantuvo normales las células de Kupffer.
Abstract The protective and regenerative effect of celery (Apium Graveolens) on rats with liver damage induced by carbon tetrachloride was studied. A total of 42 three-month-old male rats were used, divided into eight groups. The groups received different doses of celery extract before and after inducing liver damage, along with placebo and control groups. TGO, TGP, and GGT transaminases were measured. The preventive group that received 2.0 ml of celery extract showed a significant reduction in GGT levels. Histologically, celery administered before the damage reduced hepatocyte cell necrosis and maintained normal Kupffer cells.
Abstract The protective and regenerative effect of celery (Apium Graveolens) on rats with liver damage induced by carbon tetrachloride was studied. A total of 42 three-month-old male rats were used, divided into eight groups. The groups received different doses of celery extract before and after inducing liver damage, along with placebo and control groups. TGO, TGP, and GGT transaminases were measured. The preventive group that received 2.0 ml of celery extract showed a significant reduction in GGT levels. Histologically, celery administered before the damage reduced hepatocyte cell necrosis and maintained normal Kupffer cells.
Descripción
Universidad Nacional de San Agustín de Arequipa, Facultad de Ciencias Biológicas, Escuela Profesional y Académica de Ciencias de la Nutricion. Tesis para optar el título profesional de Licenciada en Nutrición Humana.
Asesor Dr. Azael Paz Aliaga
Asesor Dr. Azael Paz Aliaga
Palabras clave
Medicina tradicional, Medicina alternativa, Plantas Medicinales, Hepatitis vírica, Hígado, Roedores