Humoral immune response induced by the BBIBP-CorV Vaccine (Sinopharm) in healthcare workers: a cohort study
| dc.date.accessioned | 2023-04-05T12:46:19Z | |
| dc.date.available | 2023-04-05T12:46:19Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retro-spective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | |
| dc.identifier.issn | 24146366 | |
| dc.identifier.uri | https://doi.org/10.3390/tropicalmed7050066 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/6055 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | MDPI | es_ES |
| dc.source | Infezioni in Medicina; Vol. 28 Núm. 1 | |
| dc.title | Humoral immune response induced by the BBIBP-CorV Vaccine (Sinopharm) in healthcare workers: a cohort study | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |