Human Papillomavirus, Cytomegalovirus infection and P16 staining in breast tumors from peruvian women
| dc.date.accessioned | 2023-04-05T12:48:01Z | |
| dc.date.available | 2023-04-05T12:48:01Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Objective: To evaluate the frequency distribution of viral infections in Peruvian Breast Cancer (BC) lesions and its association with clinicopathological features. Additionally, a prospective evaluation of p16 and Tumor-infiltrating lymphocytes (TIL) levels were performed for developing a comprehensive analysis. Methods: Detection of high risk- human papillomavirus (HR- HPV) through qPCR was performed in 447 BC and 79 non-cancer frozen samples. Paired paraffin samples from 238 BC were stained with Human cytomegalovirus (HCMV) and p16 immunohistochemistry. TIL was calculated in 397 BC cases. Results: HCMV was positive in 72.5%. HR- HPV was detected in 2.9% of BC and 1.3% of non-malignant samples. P16+ was found in 28.15% and median TIL percentage was 30. HR- HPV infection was associated with non-ductal histology (p=0.003) and p16+ (p=0.017). Positive P16+ was associated with higher T stage (p=0.022), grade (p=0.009), TIL level (p=0.002), and triple-negative phenotype (p=0.021). Conclusion: HCMV is frequent, but HR- HPV infection is unusual in Peruvian BC. P16+ is associated with HR- PVH infection, high TIL and aggressive features. © 2022. All Rights Reserved. | |
| dc.identifier.issn | 15137368 | |
| dc.identifier.uri | https://doi.org/10.31557/APJCP.2022.23.5.1571 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/6128 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | Asian Pacific Organization for Cancer Prevention | es_ES |
| dc.source | Revista de Investigaciones Veterinarias del Peru; Vol. 32 Núm. 6 | |
| dc.title | Human Papillomavirus, Cytomegalovirus infection and P16 staining in breast tumors from peruvian women | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |