Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: study design and HPV DNA/p16INK4a status
| dc.date.accessioned | 2023-04-05T12:48:17Z | |
| dc.date.available | 2023-04-05T12:48:17Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | BACKGROUND: Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. METHODS: HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. RESULTS: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. CONCLUSIONS: Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide. © 2021 Wiley Periodicals LLC. | |
| dc.identifier.issn | 10970347 | |
| dc.identifier.uri | https://doi.org/10.1002/hed.26912 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/6321 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | NLM (Medline) | es_ES |
| dc.source | International Journal of Oral and Maxillofacial Surgery; Vol. 50 Núm. 1 | |
| dc.title | Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: study design and HPV DNA/p16INK4a status | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |