Ischemic stroke and six genetic variants in CRP, EPHX2, FGA, and NOTCH3 genes: a meta-analysis

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dc.contributor.authorGonzález-Giraldo Y.es_ES
dc.contributor.authorBarreto, G.E.es_ES
dc.contributor.authorFava, C.es_ES
dc.contributor.authorForero, D.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:42Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:42Z
dc.date.issued2016
dc.description.abstractBackground: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature search for 6 candidate polymorphisms and IS was conducted using HuGE Navigator, PubMed, and Google Scholar databases. Meta-Analyst program was used to calculate pooled odds ratios (ORs) with a random effects model. Results: Twenty-five published studies for 6 candidate polymorphisms were included: CRP-rs1800947 (5 studies), CRP-rs1205 (3 studies), EPHX2-rs751141 (5 studies), FGA-rs6050 (6 studies), NOTCH3-rs3815188 (3 studies), and NOTCH3-rs1043994 (3 studies), for a total number of 7,825 IS cases and 56,532 control subjects. We did not find significant pooled ORs (P values > .05) for any of the genetic variants evaluated in this work. Conclusions: Our meta-analysis results did not show significant associations between these 6 polymorphisms in 4 candidate genes and IS, despite the functional role of some of these single nucleotide polymorphisms (e.g., rs6050 in FGA gene). Future studies are needed to identify additional main genetic risk factors for IS in different populations. © 2016 National Stroke Association.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2016.05.020es_ES
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2016.05.020
dc.language.isoenges_ES
dc.publisherW.B. Saunderses_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceJournal of Stroke and Cerebrovascular Diseaseses_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleIschemic stroke and six genetic variants in CRP, EPHX2, FGA, and NOTCH3 genes: a meta-analysises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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