Evaluating three biomarkers as prognostic factors of in-hospital mortality and severity in heart failure: a prospective cohort [Avaliação de três biomarcadores como fatores de prognóstico de mortalidade intra-hospitalar e de gravidade da insuficiência cardíaca: coorte prospetiva]
| dc.date.accessioned | 2023-04-05T12:48:39Z | |
| dc.date.available | 2023-04-05T12:48:39Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Objective: To identify the relationship between red blood cell distribution width (RDW, %), interleukin-6 (IL-6) (pg/ml), high sensitivity-c-reactive protein (hs-CRP) (mg/l), in-hospital mortality and disease severity among patients with heart failure (HF). Methods: Prospective cohort. We included adults diagnosed with acute non-ischemic HF in 2015. The dependent variables were in-hospital mortality (yes or no) and disease severity. The latter was assessed with the Get With The Guidelines-HF score. We used hierarchical regression models to describe the pattern of association between biomarkers, mortality, and severity. We used the Youden index to identify the best cut-off for mortality prediction. Results: We included 167 patients; the mean age was 72.61 (SD: 11.06). The majority of patients presented with New York Heart Association classification II (40.12%) or III (43.11%). After adjusting for age and gender, all biomarkers were associated with mortality. After adding comorbidities, only IL-6 was associated. The final model with all clinical variables showed no effect from any biomarker. The best cut-off for RDW, hs-CRP and IL-6 for mortality were 14.8, 68.7 and 52.9, respectively. IL-6 presented the highest sensitivity (100%), specificity (75.35%) and area under the curve (0.91). Conclusions: No biomarker is independent from the most important clinical variables; therefore it should not be used for management modifications. © 2021 Sociedade Portuguesa de Cardiologia | |
| dc.identifier.issn | 8702551 | |
| dc.identifier.uri | https://doi.org/10.1016/j.repc.2021.03.010 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/6462 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | Sociedade Portuguesa de Cardiologia | es_ES |
| dc.source | IOP Conference Series: Earth and Environmental Science; Vol. 801 Núm. 1 | |
| dc.title | Evaluating three biomarkers as prognostic factors of in-hospital mortality and severity in heart failure: a prospective cohort [Avaliação de três biomarcadores como fatores de prognóstico de mortalidade intra-hospitalar e de gravidade da insuficiência cardíaca: coorte prospetiva] | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |