The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: Data from a multiethnic Latin American cohort

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dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorAcevedo-Vásquez, E.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.contributor.authorPastor-Asurza, C.A.es_ES
dc.contributor.authorAlfaro-Lozano, J.L.es_ES
dc.contributor.authorCucho-Venegas, J.M.es_ES
dc.contributor.authorSegami, M.I.es_ES
dc.contributor.authorWojdyla, D.es_ES
dc.contributor.authorSoriano, E.R.es_ES
dc.contributor.authorDrenkard, C.es_ES
dc.contributor.authorBrenol, J.C.es_ES
dc.contributor.authorDe Oliveira E Silva Montandon, A.C.es_ES
dc.contributor.authorLavras Costallat, L.T.es_ES
dc.contributor.authorMassardo, L.es_ES
dc.contributor.authorMolina-Restrepo, J.F.es_ES
dc.contributor.authorGuibert-Toledano, M.es_ES
dc.contributor.authorSilveira, L.H.es_ES
dc.contributor.authorAmigo, M.C.es_ES
dc.contributor.authorBarile-Fabris, L.A.es_ES
dc.contributor.authorChacón-Díaz, R.es_ES
dc.contributor.authorEsteva-Spinetti, M.H.es_ES
dc.contributor.authorPons-Estel, G.J.es_ES
dc.contributor.authorMcGwin, G. Jr.es_ES
dc.contributor.authorPons-Estel, B.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:44Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:44Z
dc.date.issued2015
dc.description.abstractPurpose: To determine the association between the number of flares systemic lupus erythematosus (SLE) patients experience and damage accrual, independently of other known risk factors. Methods: SLE patients (34 centres, nine Latin American countries) with a recent diagnosis (≤2 years) and ≥3 evaluations were studied. Disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and damage with the SLICC/ACR Damage Index (SDI). Flare was defined as an increase ≥4 points in the SLEDAI between two study visits. An ambidirectional case- crossover design was used to determine the association between the number of flares and damage accrual. Results: 901 patients were eligible for the study; 500 of them (55.5%) experienced at least one flare, being the mean number of flares 0.9 (SD: 1.0). 574 intervals from 251 patients were included in the case-crossover design since they have case and control intervals, whereas, the remaining patients did not. Their mean age at diagnosis was 27.9 years (SD: 11.1), 213 (84.9%) were women. The mean baseline SDI and SLEDAI were 1.3 (1.3) and 13.6 (8.1), respectively. Other features were comparable to those of the entire sample. After adjusting for possible confounding variables, the number of flares, regardless of their severity, was associated with damage accrual (SDI) OR 2.05, 95% CI 1.43 to 2.94, p<0.001 (OR 2.62, 95% CI 1.31 to 5.24, p=0.006 for severe and OR 1.91, 95% CI 1.28 to 2.83, p=0.001 for mild-moderate). Conclusions: The number of flares patients experience, regardless of their severity, increases the risk of damage accrual, independently of other known risk factors. © 2015, BMJ Publishing Group. All rights reserved.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1136/annrheumdis-2013-204620es_ES
dc.identifier.urihttps://doi.org/10.1136/annrheumdis-2013-204620
dc.language.isoenges_ES
dc.publisherBMJ Publishing Groupes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceAnnals of the Rheumatic Diseaseses_ES
dc.subjectBiochemistry, Genetics and Molecular Biologyes_ES
dc.subjectImmunology and Microbiologyes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#1.06.03es_ES
dc.titleThe number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: Data from a multiethnic Latin American cohortes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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