Extracellular cysteine in connexins: role as redox sensors

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dc.contributor.authorRetamal, M.A.es_ES
dc.contributor.authorGarcía, I.E.es_ES
dc.contributor.authorPinto, B.I.es_ES
dc.contributor.authorPupo, A.es_ES
dc.contributor.authorBáez, D.es_ES
dc.contributor.authorStehberg, J.es_ES
dc.contributor.authorDel Rio, R.es_ES
dc.contributor.authorGonzález, C.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T15:55:58Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T15:55:58Z
dc.date.issued2016
dc.description.abstractConnexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression. © 2016 Retamal, García, Pinto, Pupo, Báez, Stehberg, Del Rio and González.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.3389/fphys.2016.00001es_ES
dc.identifier.urihttps://doi.org/10.3389/fphys.2016.00001
dc.identifier.urihttps://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2016.00001/fulles_PE
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/26858649/es_PE
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceFrontiers in Physiologyes_ES
dc.subjectBiochemistry, Genetics and Molecular Biologyes_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#1.06.03es_ES
dc.titleExtracellular cysteine in connexins: role as redox sensorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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