Histological comparison of post-extraction alveolar bone repair treated with melatonin and calcium sulfate: an in vivo study in Cavia porcellus

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2021
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Jaypee Brothers Medical Publishers (P) Ltd
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Aim and objective: To histologically compare alveolar bone repair after tooth extraction treated with melatonin and calcium sulfate in an in vivo experimental study in guinea pigs (Cavia porcellus). Materials and methods: The study was of longitudinal, prospective, and experimental design in an animal bio-model. A total of 24 male guinea pigs were included, weighing from 700 to 900 g and separated into two experimental groups (melatonin and calcium sulfate) for three periods (15, 30, and 45 days) at 15-day intervals after surgery. The guinea pigs were randomly included into groups for the time evaluated. Results: In relation to bone repair cells using calcium sulfate, the presence of osteoblasts at 15, 30, and 45 days was 39.0 ± 63, 55.3 ± 6.0, respectively, with 61.3 ± 10.0 cells per field. Regarding bone repair cells using melatonin, the presence of osteoblasts at 15, 30, and 45 days was 25.0 ± 3.7, 49.3 ± 1.5, respectively, with 53.6 ± 5.6 cells per field. Conclusion: Both melatonin and calcium sulfate were found to be useful in bone repair at a histological and clinical level, although they present certain nonsignificant, albeit marked advantages in the bone repair process when compared with the control socket at the histological level. Clinical significance: This research allows us to know the usefulness of these easily accessible chemicals for the generation of bone repair. © 2021 Jaypee Brothers Medical Publishers. All Rights Reserved.
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https://doi.org/10.5005/jp-journals-10024-3150
 http://146.190.124.33/handle/123456789/5908
 https://pubmed.ncbi.nlm.nih.gov/34615777/
 https://cris.unfv.edu.pe/es/publications/histological-comparison-of-post-extraction-alveolar-bone-repair-t
 http://www.scopus.com/inward/record.url?scp=85115627482&partnerID=8YFLogxK
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