Effects of NSAIDsS and environmental oxygen pressure on bone regeneration [Efecto de los AINEs y la presión de oxígeno ambiental sobre la regeneración ósea]
| dc.date.accessioned | 2023-04-05T12:45:32Z | |
| dc.date.available | 2023-04-05T12:45:32Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Objective: To evaluate the effects of administering diclofenac and ketoprofen, as well as the effects of environmental oxygen pressure variation on mandibular bone regeneration. Methods: Thirty-six guinea pigs were distributed into two equal groups. Mandibular bone defects were performed on both groups. Group A was monitored under oxygen pressure at altitude (3320msl, 107mm Hg). Group B was monitored at sea level oxygen pressure (150msl, 157mm Hg). Each group was subdivided into 3 equal groups (A1, A2, A3 and B1, B2, B3). Subgroups A1 and B1 were given diclofenac; subgroups A2 and B2 ketoprofen; subgroups A3 and B3 NaCl. Bone regeneration was evaluated histologically on days 15 and 30. Results: After 15 days in the group controlled at sea level, the level of osteoblasts presented by the control subgroup was significantly higher (28.00±2.65) compared to the diclofenac subgroup (16.00±6.25) and to the ketoprofen subgroup (18.00±4.36); (p=0.041). After 15 days in the group controlled at altitude, the level of osteoblasts was significantly higher in the control subgroup (38.00±5.29) compared to the diclofenac subgroup (21.67±6.35) and to the ketoprofen subgroup (19.33±2.52); p=0.007. After 30 days in the group at sea level there was no difference found in the cell counting; p>0.05. After 30 days in the group controlled at altitude, the level of osteoblast was significantly higher in the control subgroup (58.00±4.58) compared to the diclofenac subgroup (34.33±4.73) and the ketoprofen subgroup (34.00±11.14); (p=0.003). Conclusion: The administration of diclofenac and ketoprofen produced lower mandibular bone regeneration, the effect being significantly more negative at sea level. © 2019, Universidad de Concepcion. All rights reserved. | |
| dc.identifier.issn | 7192479 | |
| dc.identifier.uri | https://doi.org/10.17126/joralres.2019.024 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/5656 | |
| dc.identifier.uri | https://www.joralres.com/index.php/JOralRes/article/view/joralres.2019.024 | es_PE |
| dc.language.iso | eng | es_ES |
| dc.publisher | Universidad de Concepcion | es_ES |
| dc.source | European Journal of General Dentistry; Vol. 10 Núm. 3 | |
| dc.title | Effects of NSAIDsS and environmental oxygen pressure on bone regeneration [Efecto de los AINEs y la presión de oxígeno ambiental sobre la regeneración ósea] | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |