Genetics of ANCA-associated vasculitides

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dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorEspinoza, L.R.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:40Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:40Z
dc.date.issued2014
dc.description.abstractThe distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clinical syndrome phenotypes and their prognosis, but also ANCA specificity; these data suggest that AAV may need reclassification. Several genes have been evaluated, including ANCA targets and those of the immune system, for example co-stimulatory molecules, signaling regulators, cytokines, Fc and other receptors, and other proteins. This article provides a review of genetic factors affecting the pathogenesis and prognosis of AAV. Further studies to determine the effect of genetic factors on the clinical syndrome phenotypes and ANCA specificity need to be performed across different ethnic groups. © Springer Science+Business Media 2014.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1007/s11926-014-0428-5es_ES
dc.identifier.urihttps://doi.org/10.1007/s11926-014-0428-5
dc.language.isoenges_ES
dc.publisherCurrent Science Inc.es_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceCurrent Rheumatology Reportses_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleGenetics of ANCA-associated vasculitideses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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