Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily mestizo population

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dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorSánchez-Zúñiga, C.es_ES
dc.contributor.authorGamboa-Cárdenas, R.V.es_ES
dc.contributor.authorAliaga-Zamudio, M.es_ES
dc.contributor.authorZevallos, F.es_ES
dc.contributor.authorTineo-Pozo, G.es_ES
dc.contributor.authorCucho-Venegas, J.M.es_ES
dc.contributor.authorMosqueira-Riveros, A.es_ES
dc.contributor.authorPerich-Campos, R.A.es_ES
dc.contributor.authorAlfaro-Lozano, J.L.es_ES
dc.contributor.authorMedina, M.es_ES
dc.contributor.authorRodríguez-Bellido Z.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.contributor.authorPastor-Asurza, C.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:38Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:38Z
dc.date.issued2015
dc.description.abstractObjective. The aim of this study was to determine whether the proportions of naive and memory CD4+ T cell are independently associated with the metabolic syndrome (MetS) in patients with SLE. Methods. This cross-sectional study was conducted in SLE patients seen at our rheumatology department between September 2013 and April 2014. CD4+ T cell subpopulations were examined by flow cytometry. The association of MetS and CD4+ T cell subpopulations was examined by Mann-Whitney U-test and by multivariable analysis, adjusting for all possible confounding variables. Results. One hundred and seventeen patients were evaluated. Their mean age was 44.6 years (s.d. 12.6), 109 (93.2%) were female and all patients were Mestizo (mixed Caucasian and Amerindian ancestry). Fifty-two patients (44.4%) presented with MetS. Disease duration was 7.6 years (s.d. 6.8). The percentage of naive CD4+ T cells was 25.0 (s.d. 12.7) and memory CD4+ T cells was 66.7 (s.d. 13.2) and the memory:naive CD4+ T cell ratio was 4.3 (s.d. 5.6). In multivariable analysis, the percentage of naive CD4+ T cells was negatively associated with the presence of MetS [odds ratio (OR) 0.959 (95% CI 0.923, 0.997), P = 0.033], whereas the percentage of memory CD4+T cells and the memory:naive CD4+ T cell ratio were positively associated with its presence [OR 1.040 (95% CI 1.003, 1.078), P = 0.031 and OR 1.238 (95% CI 1.041, 1.472), P = 0.016, respectively]. Conclusion. In the SLE patients studied, a lower percentage of naive CD4+ T cells, a higher percentage of memory CD4+ T cells and the memory:naive CD4+ T cell ratio were independently associated with the presence of MetS. This association could reflect the impact of immunosenescence among SLE patients with cardiovascular morbidity. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1093/rheumatology/keu434es_ES
dc.identifier.urihttps://doi.org/10.1093/rheumatology/keu434
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceRheumatology (United Kingdom)es_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleCirculating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily mestizo populationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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