Actividad antitumoral de biopolímeros aislados de Vibrio sp. en cáncer de mama inducido en ratas [Antitumor activity of Vibrio sp. isolated biopolymers in induced breast cancer in rats ]
| dc.date.accessioned | 2023-04-05T12:45:45Z | |
| dc.date.available | 2023-04-05T12:45:45Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Objective: To evaluate the antitumor activity of the raw extract from biopolymers isolated from the Vibrio sp. marine bacteria in breast cancer induced by N-Methyl-N-nitrosourea (MNU) in rats. Materials and methods: The Vibrio sp. marine bacteria was cultured for seven days, then the raw supernatant was filtered, precipitated and concentrated. MNU was administered in a single dose of 50 mg/kg to 39 Holtzman rats and were daily treated for 9 weeks orally: G1 (n = 13): 0.1 mL/100 g of saline solution; G2 (n = 13): 20 mg/kg of raw extract from Vibrio sp. biopolymers; G3 (n = 13): 100 mg/kg of tamoxifen; G4 (n = 11) received no MNU and only 0.1 mL/100 g of saline solution. Body weight and the appearance of breast tumors identified by palpation were assessed weekly, as well as histopathological examination at the end of treatment. Results: Seventy-seven percent of the rats in the G1 group developed tumors from week 7 onwards in an average of 2.2 tumors per animal; in contrast to the group treated with the raw biopolymer extract and tamoxifen; where only one rat (8%) in each group developed tumors after week nine of induction (p = 0.001). The histopathological results support that all the removed tumors correspond to breast ductal adenocarcinoma with different patterns: solid, papillary and cystic. Likewise, necrotic foci were evidenced in 30% of the tumors of the G1 group. Conclusion: The raw extract of biopolymers isolated from Vibrio sp. present antitumor effect in breast cancer induced in rats. © 2020, Instituto Nacional de Salud. All rights reserved. | |
| dc.identifier.issn | 17264634 | |
| dc.identifier.uri | https://doi.org/10.17843/RPMESP.2020.372.4756 | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/5804 | |
| dc.language.iso | spa | es_ES |
| dc.publisher | Instituto Nacional de Salud | es_ES |
| dc.source | PLoS Neglected Tropical Diseases; Vol. 14 Núm. 5 | |
| dc.title | Actividad antitumoral de biopolímeros aislados de Vibrio sp. en cáncer de mama inducido en ratas [Antitumor activity of Vibrio sp. isolated biopolymers in induced breast cancer in rats ] | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |