Efecto hepatoprotector del extracto acuoso de Ocimum basilicum L. (albahaca morada) en Rattus norvegicus variedad Sprague-Dawley intoxicadas con tetracloruro de carbono. Arequipa, 2014
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Nacional de San Agustín de Arequipa
Abstract
El estudio evaluó el efecto hepatoprotector del extracto acuoso de Ocimum basilicum L. ("albahaca morada") en ratas Sprague Dawley intoxicadas con tetracloruro de carbono. Se utilizaron 24 ratas divididas en cuatro grupos: un grupo blanco, dos grupos experimentales con diferentes dosis del extracto, y un grupo control con hepabionta. La actividad hepática se evaluó a los 10, 20 y 30 días. Los resultados mostraron una disminución significativa en la actividad de TGO y TGP en el grupo que recibió 1.0g/kg/día del extracto y en el grupo que recibió hepabionta, con una mejoría en la evaluación histopatológica del tejido hepático.
Abstract The study evaluated the hepatoprotective effect of the aqueous extract of Ocimum basilicum L. ("purple basil") in Sprague Dawley rats intoxicated with carbon tetrachloride. Twenty-four rats were divided into four groups: a control group, two experimental groups with different doses of the extract, and a control group with hepabionta. Hepatic activity was evaluated at 10, 20, and 30 days. The results showed a significant decrease in TGO and TGP activity in the group that received 1.0g/kg/day of the extract and in the group that received hepabionta, with an improvement in the histopathological evaluation of liver tissue.
Abstract The study evaluated the hepatoprotective effect of the aqueous extract of Ocimum basilicum L. ("purple basil") in Sprague Dawley rats intoxicated with carbon tetrachloride. Twenty-four rats were divided into four groups: a control group, two experimental groups with different doses of the extract, and a control group with hepabionta. Hepatic activity was evaluated at 10, 20, and 30 days. The results showed a significant decrease in TGO and TGP activity in the group that received 1.0g/kg/day of the extract and in the group that received hepabionta, with an improvement in the histopathological evaluation of liver tissue.
Description
Universidad Nacional de San Agustín de Arequipa, Facultad de Ciencias Biológicas, Escuela Profesional y Académica de Ciencias de la Nutricion. Tesis para optar el título profesional de Licenciada en Nutrición Humana.
Asesor Mg. Henry Diaz Murillo
Asesor Mg. Henry Diaz Murillo
Keywords
Medicina alternativa, Medicina tradicional, Plantas Medicinales, Experimentos científicos, Roedores