The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications
| dc.date.accessioned | 2023-04-05T12:45:54Z | |
| dc.date.available | 2023-04-05T12:45:54Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as coronavirus disease 2019 (COVID-19) causes cytokine release syndrome (CRS), leading to acute respiratory distress syndrome (ARDS), acute kidney and cardiac injury, liver dysfunction, and multiorgan failure. Although several studies have discussed the role of 5-lipoxygenase (5-LOX) in viral infections, such as influenzae and SARS, it remains unexplored in the pathophysiology of COVID-19. 5-LOX acts on free arachidonic acid (AA) to form proinflammatory leukotrienes (LTs). Of note, numerous cells involved with COVID-19 (e.g., inflammatory and smooth muscle cells, platelets, and vascular endothelium) widely express leukotriene receptors. Moreover, 5-LOX metabolites induce the release of cytokines (e.g., tumour necrosis factor-α [TNF-α], interleukin-1α [IL-1α], and interleukin-1β [IL-1β]) and express tissue factor on cell membranes and activate plasmin. Since macrophages, monocytes, neutrophils, and eosinophils can express lipoxygenases, activation of 5-LOX and the subsequent release of LTs may contribute to the severity of COVID-19. This review sheds light on the potential implications of 5-LOX in SARS-CoV-2-mediated infection and the anticipated therapeutic role of 5-LOX inhibitors. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG. | |
| dc.identifier.issn | 10233830 | |
| dc.identifier.uri | https://doi.org/10.1007/s00011-021-01473-y | |
| dc.identifier.uri | http://146.190.124.33/handle/123456789/5895 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | Springer Science and Business Media Deutschland GmbH | es_ES |
| dc.source | International Journal of Environmental Research and Public Health; Vol. 19 Núm. 15 | |
| dc.title | The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion |