Neuroprotective effects of the catalytic subunit of telomerase: a potential therapeutic target in the central nervous system

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dc.contributor.authorGonzález-Giraldo, Y.es_ES
dc.contributor.authorForero, D.A.es_ES
dc.contributor.authorEcheverria, V.es_ES
dc.contributor.authorGonzalez, J.es_ES
dc.contributor.authorÁvila-Rodriguez, M.es_ES
dc.contributor.authorGarcia-Segura, L.M.es_ES
dc.contributor.authorBarreto, G.E.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:09:25Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:09:25Z
dc.date.issued2016
dc.description.abstractSenescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies directed to counteract these molecular changes are of great interest for the prevention of the neurodegenerative process. Telomerase is a ribonucleoprotein composed of a catalytic subunit (TERT) and a RNA subunit (TERC). It is known that the telomerase is involved in the maintenance of telomere length and is a highly expressed protein in embryonic stages and decreases in adult cells. In the last decade, a growing number of studies have shown that TERT has neuroprotective effects in cellular and animal models after a brain injury. Significantly, differences in TERT expression between controls and patients with major depressive disorder have been observed. More recently, TERT has been associated with the decrease in reactive oxygen species and DNA protection in mitochondria of neurons. In this review, we highlight the role of TERT in some neurodegenerative disorders and discuss some studies focusing on this protein as a potential target for neuroprotective therapies. © 2016 Elsevier B.V.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1016/j.arr.2016.04.004es_ES
dc.identifier.urihttps://doi.org/10.1016/j.arr.2016.04.004
dc.language.isoenges_ES
dc.publisherElsevier Ireland Ltdes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceAgeing Research Reviewses_ES
dc.subjectBiochemistry, Genetics and Molecular Biologyes_ES
dc.subjectNeurosciencees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#1.06.03es_ES
dc.titleNeuroprotective effects of the catalytic subunit of telomerase: a potential therapeutic target in the central nervous systemes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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