Abatacept for the treatment of systemic lupus erythematosus

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dc.contributor.authorPimentel-Quiroz, V.R.es_ES
dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:31:37Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:31:37Z
dc.date.issued2016
dc.description.abstractIntroduction: Due to improvements in our understanding of the pathogenesis of systemic lupus erythematosus (SLE), several target drugs have been and are being developed. One of the possible targets in SLE is co-stimulation between antigen-presenting cells and T cells. Abatacept is a co-stimulation moderator approved for the treatment of several autoimmune diseases. There is an unmet need for drugs with a better efficacy and safety profile when treating patients with SLE.Areas covered: In this review, the authors discuss the mechanism of action of abatacept including its role in the immune system and glomeruli, and relevant information about its clinical efficacy and safety. Possible explanations for the failure of previous randomized clinical trials are also discussed.Expert opinion: Abatacept has demonstrated efficacy in other autoimmune diseases, but in SLE, randomized clinical trials have failed to achieve their primary outcome. Despite these disappointing results and based on its mechanism of action, abatacept seems to have a role in lupus nephritis and arthritis. This should be corroborated with new trials which hopefully will overcome the design pitfalls of the ones conducted to date. © 2016 Informa UK Limited, trading as Taylor & Francis Group.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1517/13543784.2016.1154943es_ES
dc.identifier.urihttps://doi.org/10.1517/13543784.2016.1154943
dc.language.isoenges_ES
dc.publisherTaylor and Francis Ltdes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceExpert Opinion on Investigational Drugses_ES
dc.subjectMedicinees_ES
dc.subjectPharmacology, Toxicology and Pharmaceuticses_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titleAbatacept for the treatment of systemic lupus erythematosuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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