Predictive factors of flares in systemic lupus erythematosus patients: data from a multiethnic Latin American cohort

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dc.contributor.authorUgarte-Gil, M.F.es_ES
dc.contributor.authorWojdyla, D.es_ES
dc.contributor.authorPastor-Asurza, C.A.es_ES
dc.contributor.authorAlarcón, G.S.es_ES
dc.contributor.authorPons-Estel, B.A.es_ES
dc.date.accessioned6/22/2022 13:33
dc.date.accessioned2022-09-30T16:54:29Z
dc.date.available6/22/2022 13:33
dc.date.available2022-09-30T16:54:29Z
dc.date.issued2018
dc.description.abstractPurpose: The purpose of this paper is to determine the factors predictive of flares in systemic lupus erythematosus (SLE) patients. Methods: A case-control study nested within the Grupo Latino Americano De Estudio de Lupus (GLADEL) cohort was conducted. Flare was defined as an increase ≥4 points in the SLEDAI. Cases were defined as patients with at least one flare. Controls were selected by matching cases by length of follow-up. Demographic and clinical manifestations were systematically recorded by a common protocol. Glucocorticoid use was recorded as average daily dose of prednisone and antimalarial use as percentage of time on antimalarial and categorized as never (0%), rarely (>0–25%), occasionally (>25%–50%), commonly (˃50%–75%) and frequently (˃75%). Immunosuppressive drugs were recorded as used or not used. The association between demographic, clinical manifestations, therapy and flares was examined using univariable and multivariable conditional logistic regression models. Results: A total of 465 cases and controls were included. Mean age at diagnosis among cases and controls was 27.5 vs 29.9 years, p = 0.003; gender and ethnic distributions were comparable among both groups and so was the baseline SLEDAI. Independent factors protective of flares identified by multivariable analysis were older age at diagnosis (OR = 0.929 per every five years, 95% CI 0.869–0.975; p = 0.004) and antimalarial use (frequently vs never, OR = 0.722, 95% CI 0.522–0.998; p = 0.049) whereas azathioprine use (OR = 1.820, 95% CI 1.309–2.531; p < 0.001) and SLEDAI post-baseline were predictive of them (OR = 1.034, 95% CI 1.005–1.064; p = 0.022). Conclusions: In this large, longitudinal Latin American cohort, older age at diagnosis and more frequent antimalarial use were protective whereas azathioprine use and higher disease activity were predictive of flares. © 2017, © The Author(s) 2017.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doi10.1177/0961203317728810es_ES
dc.identifier.urihttps://doi.org/10.1177/0961203317728810
dc.language.isoenges_ES
dc.publisherSAGE Publications Ltdes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceLupuses_ES
dc.subjectMedicinees_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.00.00es_ES
dc.titlePredictive factors of flares in systemic lupus erythematosus patients: data from a multiethnic Latin American cohortes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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