Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental [Celecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer]
Fecha
2016
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de la Frontera
Resumen
Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable to other tumor lines, concluding that Celecoxib/poli(lactic-co-glycolic) acid is a potential candidate in antitumor therapy. © 2016, Universidad de la Frontera. All rights reserved.
Descripción
Palabras clave
Medicine