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http://repositorio.ubip.org:4000/handle/123456789/5135

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Examinando Revisión por Materia "http://purl.org/pe-repo/ocde/ford#4.01.00"

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    ÍtemAcceso Abierto
    Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease
    (2016) Iturriaga, R.; Del Rio, R.; Idiaquez, J.; Somers, V.K.
    The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
  • Miniatura
    ÍtemAcceso Abierto
    REDD+ en Latinoamérica: el caso de Perú [REDD+ in Latin America: the case of Peru]
    (2013) Ladd, B.; Peri, P.L.
    The question of how developing countries like Peru can participate effectively in the REDD+ (reducing emissions from deforestation and forest degradation) policy initiative of the United Nations has been the focus of considerable debate recently. The aim of this study was to detect the main challenges associated with monitoring deforestation and forest degradation and also to analyze the policy challenges associated with implementing REDD in Peru. To participate effectively in this process, it is essential that the Peruvian national government formulates a national response since it is unlikely that provincial agencies managing natural resources will be able to develop the necessary expertise to carry out effective monitoring, reporting and verification, and because the underlying factors driving deforestation will require a large investment and a coordinated response at the country level.