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Ítem Acceso Abierto Factores sociolaborales asociados al riesgo cardiovascular según el score de Framingham en trabajadores de Lima, 2015 [Social-occupational factors associated with cardiovascular risk according to Framingham score in workers in Lima, 2015](Sociedad Argentina de Endocrinologia y Metabolismo, 2016) Mejia, C.R.; Chacón, J.I.; Cavero, M.; Orihuela, R.; Orihuela, E.Objective: To determine the social-occupational factors associated with cardiovascular risk in a population of workers of healthy private health insurance company in Lima, Peru. Methods: A cross-sectional study of secondary data from the data of workers who were seen in an institution as part of their occupational examinations. The Framingham score was used to determine the risk of having a cardiovascular event at 10 years. This score was also analysed along with other social and occupational variables were taken and shown in two populations (< 30 years or ≥30 years, according to score criteria). Statistical association was determined using generalised linear models. Results: Of the 4,134 workers examined, 71.4% (2,950) were men, and the median age was 35 years (range 18-73 years old). More than two-thirds (39%, 1,613) of workers had a low risk to minimum risk. In the multivariate statistics on those < 30 years: Male gender (adjusted prevalence ratio [aPR]: 7.53; 95% CI: 7.01-8.09) and body mass index (aPR: 1.02; 95% CI: 1.01- 1.04) increased the frequency of cardiovascular risk. For workers ≥ 30 years: Male gender (aPR: 2.78; 95% CI: 2.41-3.20), the body mass index (aPR: 1.01; 95% CI: 1.001-1.014), the notsingle marital status (aPR: 1.14; 95% CI: 1.08-1.21) and being an administrative worker (aPR: 1.06; 95% CI: 1.01-1.13) increased the frequency of cardiovascular risk. Conclusions: There are some social-occupational factors that influence cardiovascular risk. These results can be used for occupational medicine, proper monitoring, and improving lifestyles in the workers. © 2016 Sociedad Argentina de Endocrinología y Metabolismo.Ítem Acceso Abierto Neuroprotective effects of the catalytic subunit of telomerase: a potential therapeutic target in the central nervous system(Elsevier Ireland Ltd, 2016) González-Giraldo, Y.; Forero, D.A.; Echeverria, V.; Gonzalez, J.; Ávila-Rodriguez, M.; Garcia-Segura, L.M.; Barreto, G.E.Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies directed to counteract these molecular changes are of great interest for the prevention of the neurodegenerative process. Telomerase is a ribonucleoprotein composed of a catalytic subunit (TERT) and a RNA subunit (TERC). It is known that the telomerase is involved in the maintenance of telomere length and is a highly expressed protein in embryonic stages and decreases in adult cells. In the last decade, a growing number of studies have shown that TERT has neuroprotective effects in cellular and animal models after a brain injury. Significantly, differences in TERT expression between controls and patients with major depressive disorder have been observed. More recently, TERT has been associated with the decrease in reactive oxygen species and DNA protection in mitochondria of neurons. In this review, we highlight the role of TERT in some neurodegenerative disorders and discuss some studies focusing on this protein as a potential target for neuroprotective therapies. © 2016 Elsevier B.V.Ítem Acceso Abierto Relevance of the carotid body chemoreflex in the progression of heart failure(Hindawi Publishing Corporation, 2015) Andrade, D.C.; Lucero, C.; Toledo, C.; Madrid, C.; Marcus, N.J.; Schultz, H.D.; Del Rio, R.Chronic heart failure (CHF) is a global health problem affecting millions of people. Autonomic dysfunction and disordered breathing patterns are commonly observed in patients with CHF, and both are strongly related to poor prognosis and high mortality risk. Tonic activation of carotid body (CB) chemoreceptors contributes to sympathoexcitation and disordered breathing patterns in experimental models of CHF. Recent studies show that ablation of the CB chemoreceptors improves autonomic function and breathing control in CHF and improves survival. These exciting findings indicate that alterations in CB function are critical to the progression of CHF. Therefore, better understanding of the physiology of the CB chemoreflex in CHF could lead to improvements in current treatments and clinical management of patients with CHF characterized by high chemosensitivity. Accordingly, the main focus of this brief review is to summarize current knowledge of CB chemoreflex function in different experimental models of CHF and to comment on their potential translation to treatment of human CHF. © 2015 David C. Andrade et al.