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Ítem Acceso Abierto Desregulación de microARN en el cáncer: un enfoque terapéutico y diagnóstico [MicroRNA dysregulation in cancer: a therapeutic and diagnostic approach](Masson-Doyma Mexico, S.A., 2016) Tume, L.; Cisneros, C.; Sevillano, J.; Pacheco-Tapia, R.; Matos, D.; Acevedo-Espínola, R.; Ubidia-Incio, R.; Rodríguez, W.Cancer is one of the leading causes of death worldwide, and in many cases this is due to late detection of the disease, which complicates its treatment. MicroRNAs are short non-coding RNA sequences of ∼19-23 nucleotides that play a critical role in multiple cellular processes through post-transcriptional and translational regulation of specific genes, and an alteration in this regulatory mechanism leads to cancer. In this review, we discuss microRNA dysregulation in cancer, and propose applications of these small molecules in the treatment and diagnosis of cancer. © 2016 Sociedad Mexicana de OncologíaÍtem Solo Metadatos Assessment of craniofacial and dental characteristics in individuals with treacher collins syndrome. A review(Elsevier Masson s.r.l., 2021)Treacher Collins Syndrome (TCS) is a genetic disorder with predominantly autosomal dominant inheritance, associated with different mutations in specific genes. This review aimed to evaluate the facial, temporomandibular, zygomatic and bucco-dental phenotype in TCS individuals, and describe surgical and non-surgical solutions for each case in order to improve the quality of life of these individuals. A review of the literature on the craniofacial characteristics of the TCS was carried out, using the PICO strategy, and then a systematic search method was performed in Medline, Scopus, LILACS and SCIELO databases, identifying articles of impact and relevance until 10 June 2020, 240 articles were recovered and only 35 fulfilled the selection criteria. We found the main craniofacial and oral morphological characteristics of these individuals, and the possible functional alterations inducing repercussion in the stomatognathic apparatus. Among other characteristics, the most representative include hypoplasia in the zygomatic and mandibular complex, which can cause difficulty in breathing and feeding. In some cases, cleft palate and malocclusions such as anterior open bite may lead to Angle's Class II malocclusion, sometimes causing problems in the temporomandibular joint. In conclusion, individuals with TCS have specific craniofacial features including maxillary hypoplasia, altered orbital zones, mandibular retrognathia, and temporomandibular disorders. Oral deformities produce to a higher prevalence of caries and calculus formation because of poor hygiene due to the malformations present in these patients. © 2020 Elsevier Masson SASÍtem Solo Metadatos Evaluation of the craniofacial and oral characteristics of individuals with Down syndrome: a review of the literature(Elsevier Masson s.r.l., 2021)The aim of this investigation was to describe the craniofacial and oral characteristics of children and/or adolescents with and without Down syndrome (DS). A bibliographic search of the Medline database (via PubMed), Scopus and SCIELO was performed using the keywords “craniofacial characteristics”, “dental characteristics” and “Down syndrome”. Systematic reviews, observational cross-sectional and longitudinal studies were included. On the contrary, case reports, letters to the editor, editorials and opinion articles were excluded. 251 articles were recovered, and only 30 fulfilled the selection criteria. DS patients were characterized by reduced dimensions of the maxillary bone, mandible, and skull base, compared to normal patients. Likewise, some of these abnormalities influenced more frequent presentation of a class III malocclusion in these patients. On the other hand, this population group showed a higher prevalence of periodontal diseases, less risk of dental caries, and the presence of alterations in the tongue, lips, dental development and palate morphology. The quality of life of these individuals is affected by difficulties in swallowing, talking, eating or breathing through the nose. In conclusion, the craniofacial and oral characteristics of DS patients present various alterations compared to healthy patients, and these alterations have a negative impact on their quality of life. © 2021 Elsevier Masson SAS