Examinando por Autor "Zevallos, F."

Mostrando 1 - 5 de 5
  • Miniatura
    ÍtemAcceso Abierto
    Circulating CD4+CD28null and extra-thymic CD4+CD8+ double positive T cells are independently associated with disease damage in systemic lupus erythematosus patients
    (SAGE Publications Ltd, 2016) Ugarte-Gil, M.F.; Sánchez-Zúñiga, C.; Gamboa-Cárdenas, R.V.; Aliaga-Zamudio, M.; Zevallos, F.; Tineo-Pozo, G.; Cucho-Venegas, J.M.; Mosqueira-Riveros, A.; Medina, M.; Perich-Campos, R.A.; Alfaro-Lozano, J.L.; Rodriguez-Bellido, Z.; Alarcón, G.S.; Pastor-Asurza, C.A.
    Objective: To determine whether circulating CD4+CD28null and extra-thymic CD4+CD8+ double positive (DP) T cells are independently associated with damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This cross-sectional study was conducted between September 2013 and April 2014 in consecutive SLE patients from our Rheumatology Department. CD4+CD28null and CD4+CD8+ DP T-cell frequencies were analyzed by flow-cytometry. The association of damage (SLICC/ACR Damage Index, SDI) and CD4+CD28null and CD4+CD8+ DP T cells was examined by univariable and multivariable Poisson regression models, adjusting for possible confounders. All analyses were performed using SPSS 21.0. Results: Patients' (n = 133) mean (SD) age at diagnosis was 35.5 (16.8) years, 124 (93.2%) were female; all were mestizo (mixed Caucasian and Amerindian ancestry). Disease duration was 7.4 (6.8) years. The SLE Disease Activity Index was 5.5 (4.2), and the SDI 0.9 (1.2). The percentages of CD4+CD28null and CD4+CD8+ DP T cells were 17.1 (14.4) and 0.4 (1.4), respectively. The percentage of CD4+CD28null and CD4+CD8+ DP T cells were positively associated with a higher SDI in both univariable (rate ratio (RR) 1.02, 95% confidence interval (CI): 1.01-1.03 and 1.17, 95% CI: 1.07-1.27, respectively; p < 0.001 for both) and multivariable analyses RR 1.02, 95% CI: 1.01-1.03, p = 0.001 for CD4+CD28null T cells and 1.28, 95% CI: 1.13-1.44, p < 0.001 for CD4+CD8+ DP T cells). Only the renal domain remained associated with CD4+CD28null in multivariable analyses (RR 1.023 (1.002-1.045); p = 0.034). Conclusions: In SLE patients, CD4+CD28null and CD4+CD8+ DP T cells are independently associated with disease damage. Longitudinal studies are warranted to determine the predictive value of these associations. © The Author(s) 2015.
  • Miniatura
    ÍtemAcceso Abierto
    Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily mestizo population
    (Oxford University Press, 2015) Ugarte-Gil, M.F.; Sánchez-Zúñiga, C.; Gamboa-Cárdenas, R.V.; Aliaga-Zamudio, M.; Zevallos, F.; Tineo-Pozo, G.; Cucho-Venegas, J.M.; Mosqueira-Riveros, A.; Perich-Campos, R.A.; Alfaro-Lozano, J.L.; Medina, M.; Rodríguez-Bellido Z.; Alarcón, G.S.; Pastor-Asurza, C.A.
    Objective. The aim of this study was to determine whether the proportions of naive and memory CD4+ T cell are independently associated with the metabolic syndrome (MetS) in patients with SLE. Methods. This cross-sectional study was conducted in SLE patients seen at our rheumatology department between September 2013 and April 2014. CD4+ T cell subpopulations were examined by flow cytometry. The association of MetS and CD4+ T cell subpopulations was examined by Mann-Whitney U-test and by multivariable analysis, adjusting for all possible confounding variables. Results. One hundred and seventeen patients were evaluated. Their mean age was 44.6 years (s.d. 12.6), 109 (93.2%) were female and all patients were Mestizo (mixed Caucasian and Amerindian ancestry). Fifty-two patients (44.4%) presented with MetS. Disease duration was 7.6 years (s.d. 6.8). The percentage of naive CD4+ T cells was 25.0 (s.d. 12.7) and memory CD4+ T cells was 66.7 (s.d. 13.2) and the memory:naive CD4+ T cell ratio was 4.3 (s.d. 5.6). In multivariable analysis, the percentage of naive CD4+ T cells was negatively associated with the presence of MetS [odds ratio (OR) 0.959 (95% CI 0.923, 0.997), P = 0.033], whereas the percentage of memory CD4+T cells and the memory:naive CD4+ T cell ratio were positively associated with its presence [OR 1.040 (95% CI 1.003, 1.078), P = 0.031 and OR 1.238 (95% CI 1.041, 1.472), P = 0.016, respectively]. Conclusion. In the SLE patients studied, a lower percentage of naive CD4+ T cells, a higher percentage of memory CD4+ T cells and the memory:naive CD4+ T cell ratio were independently associated with the presence of MetS. This association could reflect the impact of immunosenescence among SLE patients with cardiovascular morbidity. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
  • Miniatura
    ÍtemAcceso Abierto
    High prolactin levels are independently associated with damage accrual in systemic lupus erythematosus patients
    (SAGE Publications Ltd, 2014) Ugarte-Gil, M.F.; Gamboa-Cárdenas, R.V.; Zevallos, F.; Medina, M.; Cucho-Venegas, J.M.; Perich-Campos, R.A.; Alfaro-Lozano, J.L.; Rodriguez-Bellido, Z.; Alarcón, G.S.; Pastor-Asurza, C.A.
    Objective: to determine whether prolactin levels are independently associated with disease damage in systemic lupus erythematosus (SLE) patients. Methods: these cross-sectional analyses were conducted in SLE patient members of the Almenara Lupus Cohort who were seen between January 2012 and June 2013. Disease damage was ascertained with the System Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). Prolactin was measured in ng/ml. The association between prolactin levels and the SDI (total and its domains) was evaluated using Spearman's correlation. Subsequently, adjusted Poisson regression models were performed to evaluate these associations. Results: 160 patients were included. 147 (91.9%) were female; their median age at diagnosis was 33.4 (interquartile range (IQR): 26.0-44.3) years; their disease duration was 5.5 (IQR: 2.6-9.7) years. The median prolactin value was 16.8 (IQR: 11.8-24.5) ng/ml. After adjusting for confounders in the Poisson regression model the estimated rate ratios (RR) and 95% confidence interval (CI) for each 10 ng/ml increment of prolactin were 1.13 (95% CI 1.60-1.20, p<0.001) for the total SDI score, 1.15 (1.03-1.28, p=0.003) for the renal domain and 1.41 (1.11-1.79, p=0.003) for the cardiac/peripheral vascular domains. Conclusions: there was a positive association between prolactin levels and the SDI (overall and its renal and cardiac/peripheral vascular domains), independently of other well-known risk factors. © The Author(s), 2014.
  • Miniatura
    ÍtemAcceso Abierto
    Prolactin levels are associated with a pro-inflammatory body mass distribution among women with systemic lupus erythematosus
    (SAGE Publications Ltd, 2017) Elera-Fitzcarrald C.; Ugarte-Gil, M.F.; Gamboa-Cárdenas, R.V.; Zevallos, F.; Medina, M.; Cucho-Venegas, J.M.; Perich-Campos, R.A.; Alfaro-Lozano, J.L.; Rodriguez-Bellido, Z.; Alarcón, G.S.; Pastor-Asurza, C.A.
    Objectives The objective of this study was to determine whether prolactin levels are associated with a pro-inflammatory body mass distribution in women with systemic lupus erythematosus (SLE). Methods This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015. Prolactin was measured in ng/ml. Body mass distribution was measured by dual energy x-ray absorptiometry and it was divided into subtotal (whole body excluding the head), subtotal bone mineral content, lean mass index (appendicular lean mass/height2), subtotal trunk and leg fat percentages and trunk-to-leg fat ratio. The association between prolactin levels and body mass distribution components was evaluated by univariable and multivariable linear regression models adjusting for possible confounders. Results One hundred and eighty-five patients were evaluated; their mean (SD) age at diagnosis was 34.8 (13.8) years; nearly all patients were Mestizo. Patients included in this study were comparable to the rest of the cohort in terms of age, disease duration, SLEDAI, SDI and body mass index. Disease duration was 7.3 (6.6) years. The SLEDAI was 5.2 (4.3) and the SDI 0.9 (1.3). Prolactin levels were 18.9 (16.7) ng/ml. In univariable analyses, prolactin was negatively associated with bone mineral density, bone mineral content, leg fat percentage and lean mass index, and positively associated with trunk-to-leg fat ratio. In the multivariable analyses, prolactin was negatively associated with bone mineral content and positively associated with trunk-to-leg fat ratio. Conclusions Higher prolactin levels are associated with a pro-inflammatory body mass distribution in SLE patients. © 2017 SAGE Publications.
  • Miniatura
    ÍtemAcceso Abierto
    Serum uric acid levels contribute to new renal damage in systemic lupus erythematosus patients
    (Springer London, 2017) Reátegui-Sokolova, C.; Ugarte-Gil, M.F.; Gamboa-Cárdenas, R.V.; Zevallos, F.; Cucho-Venegas, J.M.; Alfaro-Lozano, J.L.; Medina, M.; Rodriguez-Bellido, Z.; Pastor-Asurza, C.A.; Alarcón, G.S.; Perich-Campos, R.A.
    This study aims to determine whether uric acid levels contribute to new renal damage in systemic lupus erythematosus (SLE) patients. This prospective study was conducted in consecutive patients seen since 2012. Patients had a baseline visit and follow-up visits every 6 months. Patients with ≥2 visits were included; those with end-stage renal disease (regardless of dialysis or transplantation) were excluded. Renal damage was ascertained using the SLICC/ACR damage index (SDI). Univariable and multivariable Cox-regression models were performed to determine the risk of new renal damage. Uric acid was included as a continuous and dichotomous (per receiving operating characteristic curve) variable. Multivariable models were adjusted for age at diagnosis, disease duration, socioeconomic status, SLEDAI, SDI, serum creatinine, baseline use of prednisone, antimalarials, and immunosuppressive drugs. One hundred and eighty-six patients were evaluated; their mean (SD) age at diagnosis was 36.8 (13.7) years; nearly all patients were mestizo. Disease duration was 7.7 (6.8) years. Follow-up time was 2.3 (1.1) years. The SLEDAI was 5.2 (4.3) and the SDI 0.8 (1.1). Uric acid levels were 4.5 (1.3) mg/dl. During follow-up, 16 (8.6%) patients developed at least one new point in the renal domain of the SDI. In multivariable analyses, uric acid levels (continuous and dichotomous) at baseline predicted the development of new renal damage (HR 3.21 (1.39–7.42), p 0.006; HR 18.28 (2.80–119.48), p 0.002; respectively). Higher uric acid levels contribute to the development of new renal damage in SLE patients independent of other well-known risk factors for such occurrence. © 2017, International League of Associations for Rheumatology (ILAR).