Examinando por Autor "Rojas-Contreras, C."

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    Enfermedad por citomegalovirus en pacientes receptores de trasplante de corazón en un centro de referencia nacional [Cytomegalovirus disease in post-heart-transplant patients at a national reference center]
    (Sociedad Chilena de Infectologia, 2016) Rojas-Contreras, C.; de La Cruz-Ku, G.; Valcarcel-Valdivia, B.
    Introduction: Heart transplantation remains as the treatment of choice when the heart failure is refractory to the medical or surgical therapy. Therefore, cytomegalovirus disease is an important post-heart-transplant infectious complication. Aims: To describe the prevalence and clinical characteristics of the cytomegalovirus disease after heart transplant surgery. Materials and Methods: A retrospective, descriptive study was conducted. It enrolled 35 heart-transplant patients attended in the Cardiovascular National Institute (INCOR), between 2010 and 2015. The information was obtained through the review of medical records. The demographic and relevant clinical variables were analyzed for the cytomegalovirus disease cases. Results: The population mean age was 39.49 ± 15.07 years and most of them were male patients (63%). The prevalence of the cytomegalovirus disease was 5.7% (two patients), both were seronegative for cytomegalovirus before transplantation. One of the patients had the disease before finishing the valganciclovir prophylaxis and the other after the end of it. Conclusion: The prevalence of the cytomegalovirus disease is slightly lower than in other studies. Moreover, the cytomegalovirus disease can remit with a prompt diagnosis and the proper medical treatment. © 2016, Sociedad Chilena de Infectologia. All rights reserved.
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    Neonato con ventriculitis causada por Empedobacter brevis: reporte de un caso en Perú [Neonate with ventriculitis caused by Empedobacter brevis: Report of a case in Peru]
    (Instituto Nacional de Salud, 2018) Rojas-Contreras, C.; De La Cruz-Ku, G.; Eyzaguirre-Sandoval, M.E.; Valcarcel-Valdivia, B.
    Infections caused by rare micro-organisms are the subject of research, as researchers are encouraged to find the necessary health measures to prevent and treat the disease, as well as the search for new insights into human-microbial interactions. This report describes the case of a newborn boy diagnosed with hydrocephalus and myelomeningocele who developed ventriculitis and sepsis from resistant Empedobacter brevis. This case highlights the unexpected identification of this bacterium in the cerebrospinal fluid and its multi-resistant pattern, which was crucial for proper therapeutic management. This bacterium shows a mixture of different etiologies in the analysis of cerebrospinal fluid. © 2018, Instituto Nacional de Salud. All rights reserved.
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    Reporte de caso de resistencia al ganciclovir en enfermedad por citomegalovirus postrasplante cardiaco [Resistance to ganciclovir in cytomegalovirus infection after heart transplant: case report]
    (Instituto Nacional de Salud, 2018) Rojas-Contreras, C.; De La Cruz-Ku, G.; Vilcarromero, S.; Villacaqui Ayllon, R.; Valcarcel-Valdivia, B.
    Cytomegalovirus infection after a heart transplant is a recurrent medical condition. Its frequency increases when the donors are serum-positive, and the recipients are serum-negative to this virus. In the pediatric population, the infection only develops in a small percentage and the patients rarely present resistance to conventional treatment with ganciclovir and valganciclovir. We presented the first report of a pediatric case of the cytomegalovirus infection resistant to ganciclovir and valganciclovir after a heart transplant in a Peruvian public hospital with an unusual presentation. The resistance to these drugs was evident after 277 days of evolution of the disease considering the non-remission of the symptomatology and the persistence of an elevated viral load. The administration of foscarnet led to a clinical and laboratory improvement until remission of the disease. © 2018, Instituto Nacional de Salud. All rights reserved.