Examinando por Autor "Mendoza-Azpur, G."
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Ítem Acceso Abierto Adiponectin, leptin and TNF-α serum levels in obese and normal weight peruvian adults with and without chronic periodontitis(Medicina Oral S.L., 2015) Mendoza-Azpur, G.; Castro, C.; Peña, L.; Guerrero, M.-E.; de la Rosa, M.; Mendes, C.; Chambrone, L.Background: TNF-α, an adipokine involved in systemic inflammation and a member of a group of cytokines that stimulate the acute phase reaction, has been related to the pathogenesis of both periodontitis and obesity. The objective of this study was to assess the serum levels of adiponectin, leptin and TNF-α of periodontally healthy normal weight (NW) patients, NW patients with chronic periodontitis (CP), periodontally healthy obese patients and obese patients with CP. Material and Methods: Ninety-three patients were enrolled in this cross-sectional study: 30 periodontally healthy NW patients; 18 NW patients with CP; 21 periodontally healthy obese patients; and 24 obese patients with CP. Analyses included clinical and anthropometric outcomes, as well as the assessment of serum levels of adiponectin, leptin and TNF-α by enzyme linked immunosorbent assay (ELISA) or fully automated chemiluminescence immunoassay. One-Way ANOVA, Kruskal-Wallis One-Way on Ranks, Dunn's Test and multivariable logistic regression (MLR) analyses were conducted to estimate the degree of association between periodontitis and obesity. Results: Obese patients with CP showed significant more bleeding sites than the other three groups (p<0.05). Moreover, patients from the NWCP and OPH showed similar BOP percentages, as well as OPH group showed more bleeding sites than the NWPH group (p<0.05). The OPH group showed similar levels of adiponectin and leptin than the OCP group, but significantly higher than the NWPH and NWCP groups(p<0.05). MLR analyses showed that obesity was positively associated with the percentage of sites with bleeding on probing, with an odds ratio of 0.93 (95% confidence interval: -0.88, - 0.98; p=0.012). Conclusions: The serum levels of adiponectin, leptin and TNF-α were not influenced by CP. Obese patients showed almost 10% more sites with BoP. In chronic periodontitis patients, obese subjects presented significant more BOP sites than normal weight subjects. © Medicina Oral S. L. C.I.F.Ítem Acceso Abierto Assessment of marginal peri-implant bone-level short-length implants compared with standard implants supporting single crowns in a controlled clinical trial: 12-month follow-up(Quintessence Publishing Co. Inc., 2016) Mendoza-Azpur, G.; Lau, M.; Valdivia, E.; Rojas, J.; Muñoz, H.; Nevins, M.In oral rehabilitation, crown-to-root ratio is accepted as an indicator of bone loss, and this concept was transferred to implants. Recent studies have indicated that there is no significant difference between short and standard implants. The aim of this study was to compare marginal bone level alteration through radiographic evaluation and clinical parameters between short and standard implants supporting single crowns. This prospective clinical trial study included 82 systemically healthy, nonsmoking subjects. Patients were divided into two groups: one group for short dental implants measuring 5.5 or 7 mm, and one group for standard dental implants measuring 10 or 12 mm, in accordance with the individual needs of the patient. A clinical dental history was taken for each subject, including model casts, dental radiography, and cone beam computed tomography. A periapical analysis was also performed using ImageJ computer software to establish the initial bone measurement and periapical bone loss. A statistically significant difference was found in favor of the standard-length implants after 12 months, with greater gingival recession around the implant; however, bone loss in the short implants did not exceed 0.53 mm. The treatment with 5.5- to 7-mm-length implants is as reliable as treatment with 10- or 12-mm implants. Peri-implant bone loss is minimal, and therefore use of short implants can be recommended as treatment for the restoration of partially edentulous patients without the need for splinted crowns. © 2016 by Quintessence Publishing Co Inc.Ítem Acceso Abierto Biodegradation of three different collagen membranes: a histological study(Ariesdue, 2016) Olaechea, A.; Mendoza-Azpur, G.; Valdivia, E.; Perini, G.R.Aim: The aim of this study was to evaluate in vivo the absorption rate of three membranes: bovine collagen (GenDerm, Baumer, Brazil), collagen (Genoss, Dentium, Korea) and porcine dermis membrane (Kytinon M.O.R., Asmopul, Argentina). The additional aims were to evaluate blood vessel penetration and fiber collagen penetration in the early wound healing process. Materials and Methods: Four dogs were used for the study and the membranes were applied by subperiosteal placement and analyzed after 15, 30, 60 and 90 days. Results" The absorption rate of <35% at 15 days was similar for all the membranes. At 30 days, rates between 35% and 65% were observed. After 60 days, only the bovine collagen membrane (GenDerm, Baumer SA, Brazil) was found to have achieved >65% absorption. This bovine collagen membrane was completely absorbed after 90 days. At this time point absorption of the bovine collagen (Collagen®, Dentium, Korea) was >65%, while absorption of the porcine dermis (Kytinon®, Asmopul, Argentina) was found to be between just 35% and 65%. Conclusion: Blood vessel penetration and fiber collagen penetration in the three membranes showed significant differences, with faster vascularization and collagen penetration in the more rapidly absorbed membranes. © ariesdue.Ítem Acceso Abierto Histomorphometric evaluation of ridge preservation with and without connective tissue graft over buccal plate using different types of bone substitute: An animal study(Lippincott Williams and Wilkins, 2015) Mendoza-Azpur, G.; Olaechea, A.; Pinazo, M.; Gomez, C.; Salinas, E.; de la Rosa, M.; Khouly, I.Purpose: The aim of this investigation was to assess the efficacy of using subepithelial connective tissue graft (CTG) over the buccal plate in conjunction with 2 different bone graft materials in fresh extraction sites. Materials and Methods: Five mongrel dogs were used. Bilateral third (P3) mandibular premolars were extracted atraumatically. Animals were randomly divided in the 4 experimental groups: no CT (NCT) + anorganic bovine bone (ABB), NCT + biphasic calcium phosphate (BCP), CT + ABB, and CT + BCP. This study evaluated tissue healing at 15, 30, 60, 90, and 120 days after socket preservation, using histologic and histomorphometric analyses. Results: The main finding showed that all groups presented similar results with minor differences regardless of the use of CTG and type of bone substitute. A greater amount of residual graft particles was found when ABB was used. No differences in the histologic and histomorphometric analysis were found when comparing the use of CTG with NCTG for ridge preservation procedure. Conclusion: Within the limitations of this animal study, the use of CTG to overbuild the buccal plate at time of tooth extraction did not affect the quality of bone regeneration. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.Ítem Acceso Abierto Tissue engineering therapy for atrophic maxilla using minimally manipulated CD90 and CD105 bone marrow stem cells: a case report(Quintessence Publishing Co. Inc., 2017) Valdivia, E.; Mendoza-Azpur, G.; Pando, J.; Cornejo, H.; Carrasco, A.; Nevins, M.; Kim, D.Bone deficiencies in the jaws of edentulous patients limit the possibility of successful placement and osseointegration of endosseous implants. Bone resorption is defined as a vertical and horizontal loss of quality and quantity in the residual bone ridges; lack of bone structure requires bone grafting procedures to enable implant placement and to improve the function, predictability, and longevity of implants. The objective of this case study was to demonstrate the feasibility of a novel cell therapy treatment for localized jaw bone defects with tissue repair cells composed of a mixture of bone marrow-derived cells, including CD90+ mesenchymal stem cells and CD105+ monocytes/macrophages, and xenograft blocks, in what would be a safe and efficacious approach to the regeneration of localized craniofacial bone defects. The use of stem cells represents an alternative that could offer improved results, better quality histologically, and greater quantity in millimeters of tissue in bone regeneration. © 2017 by Quintessence Publishing Co Inc.