Examinando por Autor "Chambrone, L."

Mostrando 1 - 5 de 5
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    Adiponectin, leptin and TNF-α serum levels in obese and normal weight peruvian adults with and without chronic periodontitis
    (Medicina Oral S.L., 2015) Mendoza-Azpur, G.; Castro, C.; Peña, L.; Guerrero, M.-E.; de la Rosa, M.; Mendes, C.; Chambrone, L.
    Background: TNF-α, an adipokine involved in systemic inflammation and a member of a group of cytokines that stimulate the acute phase reaction, has been related to the pathogenesis of both periodontitis and obesity. The objective of this study was to assess the serum levels of adiponectin, leptin and TNF-α of periodontally healthy normal weight (NW) patients, NW patients with chronic periodontitis (CP), periodontally healthy obese patients and obese patients with CP. Material and Methods: Ninety-three patients were enrolled in this cross-sectional study: 30 periodontally healthy NW patients; 18 NW patients with CP; 21 periodontally healthy obese patients; and 24 obese patients with CP. Analyses included clinical and anthropometric outcomes, as well as the assessment of serum levels of adiponectin, leptin and TNF-α by enzyme linked immunosorbent assay (ELISA) or fully automated chemiluminescence immunoassay. One-Way ANOVA, Kruskal-Wallis One-Way on Ranks, Dunn's Test and multivariable logistic regression (MLR) analyses were conducted to estimate the degree of association between periodontitis and obesity. Results: Obese patients with CP showed significant more bleeding sites than the other three groups (p<0.05). Moreover, patients from the NWCP and OPH showed similar BOP percentages, as well as OPH group showed more bleeding sites than the NWPH group (p<0.05). The OPH group showed similar levels of adiponectin and leptin than the OCP group, but significantly higher than the NWPH and NWCP groups(p<0.05). MLR analyses showed that obesity was positively associated with the percentage of sites with bleeding on probing, with an odds ratio of 0.93 (95% confidence interval: -0.88, - 0.98; p=0.012). Conclusions: The serum levels of adiponectin, leptin and TNF-α were not influenced by CP. Obese patients showed almost 10% more sites with BoP. In chronic periodontitis patients, obese subjects presented significant more BOP sites than normal weight subjects. © Medicina Oral S. L. C.I.F.
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    Association among stress, salivary cortisol levels, and chronic periodontitis
    (2013) Refulio, Z.; Rocafuerte, M.; de la Rosa, M.; Mendoza, G.; Chambrone, L.
    Purpose: Chronic periodontitis (CP) seems to be associated with stress and depression, but little information on this possible association is available in the literature. Thus, the objective of this study was to evaluate the association among stress, the salivary cortisol level (SCL), and CP. Methods: Seventy systemically healthy subjects were included in the study from January to September 2011. Full medical and dental histories were obtained, and the following measurements were recorded: 1) probing depth; 2) clinical attachment level; 3) bleeding on probing; and 4) tooth mobility. Saliva samples were collected for the evaluation of SCL (via a highly sensitive electrochemiluminescence immunoassay), and all subjects also answered a questionnaire (i.e., the Zung Self-rating Depression Scale). The odds ratio (OR) with a 95% confidence interval (CI) was calculated, and one way analysis of variance and the Tukey-Kramer method were performed. Results: A total of 36 subjects with CP (51.4%) and 34 without CP were evaluated. Of them, all of the subjects with CP and one periodontally healthy subject were diagnosed with depression. Subjects with moderate CP had statistically significantly higher levels of SCL than subjects with a diagnosis of slight CP (P=0.006). Also, subjects with severe CP showed the same outcome when compared to those with slight CP (P=0.012). In addition, 46 subjects presented high SCL whereas 24 had a normal level. CP was found to be correlated with the SCL, with an OR of 4.14 (95% CI, 1.43 to 12.01). Conclusions: Subjects with a high SCL and depression may show an increased risk for CP. © 2013 Korean Academy of Periodontology.
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    Association of -1082 interleukin-10 gene polymorphism in peruvian adults with chronic periodontitis
    (Medicina Oral, Patologia Oral y Cirugia Bucal, 2014) Chambrone, L.; Ascarza, A.; Guerrero, M.-E.; Pannuti, C.; de la Rosa, M.; Salinas-Prieto, E.; Mendoza, G.
    Objectives: The aim of this study was to assess association of the -1082 IL-10 gene polymorphism with chronic periodontitis CP in a Peruvian population.Study Design: Samples of venous blood and DNA were obtained from 106 Peruvian subjects: a) 53 periodontally healthy; and b) 53 with CP. The association of the -1082 IL-10 promoter sequences was assessed by Polymerase chain reaction-restriction fragment length polymorfism (PCR-RFLP). Student’s t test were used to assess the clinical parameters, as well as the χ2 test and the odds ratio (OR), with 95% confidence intervals (CI) used performed for estimates regarding genotype and allele frequencies.Results: There were statistically significant differences between groups regarding the mean bleeding on probing, mean attachment level and mean probing depth (p < 0.00001) indicating that the matching based on the evaluated groups was adequate. The χ2 test found a statistically significant imbalance of genotypes between groups (p = 0.0172). The prevalence of CP was significantly higher in subjects harboring at least one A allele at position -1082 (AA and GA genotypes) in comparison to patients with the GG genotype (OR = 2.96; CI: 0.52; 5.41; p = 0.0099). Equally, subjects with the AA genotype were significantly associated to a diagnosis of CP (OR = 2.71; CI: 0.38; 5.04; p = 0.0231). On the other hand, subjects presenting a healthy periodontal status presented at least one G allele in comparison with the AA genotype (OR = 0.37; CI: 0.05, 0.69; p = 0.0231). For subjects with the GG genotype, the same positive association was observed (OR = 0.34; CI: 0.06, 0.62; p = 0.0099). There were no significant differences between groups amongst subjects with the GA genotype (OR = 1.19; CI: 0.22, 2.16; p = 0.6774).Conclusions: Within the limits of this study, IL-10 gene polymorphism at position -1082 does not appear to be associated to CP. Conversely, subjects with AA genotype seem to be at an increased risk of developing CP. © Medicina Oral S. L.
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    Influence of keratinized tissue on spontaneous exposure of submerged implants: classification and clinical observations
    (Ariesdue, 2014) Mendoza, G.; Reyes, J.D.; Guerero, M.E.; Rosa, G M.D.L.; Chambrone, L.
    Aim The reasons for spontaneous early exposure (SEE) of dental implants during healing have not been established yet. The objective of this study was to assess whether the width of keratinized tissue (KT) and other site-related conditions could be associated with implants' SEE.Materials and methods Data from 500 implants placed in 138 non-smoking patients, between September 2009 and June 2010, were evaluated. Implants were submerged and allowed to heal for 3 to 6 months. At baseline, the following conditions were documented: the presence of keratinized tissue width > 2 mm; the type of implant site (i.e. fresh extraction socket or edentulous alveolar ridge); concomitant use of guided tissue regeneration. During the healing period, the occurrence of partial or total implants SEE was recorded; thus, a mixed-effects logistic regression analysis was performed to investigate the association between implant site conditions and implant exposure. Results One hundred and eighty-five implants (37.0%) remained submerged after healing and were classified as Class I, whereas 215 (43.0%) showed partial spontaneous early exposure (SEE) at the first week after implant placement (Class II), and 100 implants (20.0%) developed more extensive exposures (Class III). The variables, baseline width of KT (p = 0.18), fresh extraction socket (p = 0.88) and guided tissue regeneration (GTR) plus bone substitutes (p = 0.42), were not found to be correlated with implants SEE, with an odds ratio (OR) of 1.29 (95% confidence interval: -0.12-0.63), 1.03 (95% confidence interval: -0.46-0.53) and 1.22 (95% confidence interval: -0.29-0.68), respectively. Conclusion It was not possible to establish an association between SEE and some implant-related factors; therefore, further investigations focused on the reasons associated to implants' SEE are needed. © ariesdue.
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    Predictors of peri-implant bone loss during long-term maintenance of patients treated with 10-mm implants and single crown restorations
    (2013) De La Rosa M.; Rodríguez A.; Sierra K.; Mendoza, G.; Chambrone, L.
    Purpose: The aim of this retrospective study was to evaluate the predictors of peri-implant bone loss in a sample of patients treated with 10-mm implants and single crowns who underwent periodontal/periimplant maintenance (PM) in a Mexican private periodontal practice. Materials and Methods: Outcomes of a group of systemically healthy, partially edentulous patients attended up to July 2012 were assessed. Patient data were considered for inclusion if they involved treatment of partially edentulous sites with 10-mm-long implants and single crown restorations, as well as at least 3 years of regular PM following implant placement. Peri-implant bone loss was evaluated from data recorded at the most recent examination. Logistic regression analysis was performed to investigate associations between peri-implant bone loss and sex, duration of PM, location and number of implants placed per patient, region of the mouth, smoking status, type of implant, and retention of restoration. Results: A sample of 104 subjects who had been treated with four different types of dental implants and maintained for at least 3 years was selected. Of the 148 implants placed and followed for an average period of continuing PM of 6 years (range, 3 to 15 years), only one implant (1.8%) was lost. The outcomes of logistic regression analysis showed that the independent variables smoking, retention of restoration (cemented vs screw-retained), and type of implant (internal-or external-hex) were found to be correlated with peri-implant bone loss, with odds ratios of 39.64, 4.85, and 0.04, respectively. Conclusions: Peri-implant bone loss was significantly associated with smoking status, the type of implant (ie, externally hexed), and type of retention (ie, cemented). Overall, all patients maintained low rates of bone loss. © 2013 by Quintessence Publishing Co Inc.